| Supplier |
CD BioSciences |
| Product # |
AMA-0615 |
| Pricing |
100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB
|
| Product Usage Information Dilution |
Western Blotting (1:1000)
|
| Reactivity |
Human, Mouse, Rat, Hamster, Pig
|
| Gene ID |
5747
|
| UniProt ID |
|
| MW (Target) |
125 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr397 of human FAK. Antibodies are purified by protein A and peptide affinity chromatography.
|
| Background |
Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK.
|