Phospho-eNOS (Ser1177) (C9C3) Rabbit Antibody

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Supplier CD BioSciences
Product # AMA-0393
Pricing 100 µl/300 µL, Inquire
Product Category Antibodies
Application WB, IP
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:25)
Reactivity Human, Bovine, Pig
Host Rabbit
Gene ID 4846
UniProt ID
Source/Isotype Rabbit IgG
MW (Target) 140 kDa
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser1177 of human eNOS.
Background Endothelial nitric-oxide synthase (eNOS) is an important enzyme in the cardiovascular system. It catalyzes the production of nitric oxide (NO), a key regulator of blood pressure, vascular remodeling, and angiogenesis The activity of eNOS is regulated by phosphorylation at multiple sites. The two most thoroughly studied sites are the activation site Ser1177 and the inhibitory site Thr495 Several protein kinases including Akt/PKB, PKA, and AMPK activate eNOS by phosphorylating Ser1177 in response to various stimuli In contrast, bradykinin and H2O2 activate eNOS activity by promoting both Ser1177 phosphorylation and Thr495 dephosphorylation.
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