ZJ 43
ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki = 0.8 and 23 nM, respectively). It inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) and decreases the deleterious effects of excessive extracellular glutamate. ZJ 43 has been shown to reduce neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduce locomotor activity in the PCP-model of schizophrenia.
| Supplier | BOC Sciences |
|---|---|
| Product # | 723331-20-2 |
| Pricing | Inquire |
| Cas | 723331-20-2 |
| Molecular Weight | 304.3 |
| Molecular Formula | C12H20N2O7 |
| Canonical SMILES | CC(C)CC(C(=O)O)NC(=O)NC(CCC(=O)O)C(=O)O |