Recombinant mouse Carboxypeptidase E,His-tagged

CarboxypeptidaseE (CPE), also known as Carboxypeptidase H or enkephalin convertase.Carboxypeptidase E cleaves C-terminal amino acid residues and is involved inneuropeptide processing. It is a peripheral membrane protein. CPEspecifically binds regulated secretory pathway proteins, includingprohormones, but not constitutively secreted proteins. Carboxypeptidase Eappears to have several functions. The active form of carboxypeptidase E wasshown to be in secretory vesicles, where it acts as an exopeptidase toactivate neuropeptides, It does that by cleaving off basic C-terminal aminoacids, producing the active form of the peptide. Products of carboxypeptidaseE include insulin, enkephalin, and most other neuroendocrine peptides.It hasalso been proposed that membrane-associated carboxypeptidase E acts as asorting signal for regulated secretory proteins in the trans-Golgi network ofthe pituitary and in secretory granules; regulated secretory proteins aremostly hormones and neuropeptides. Mice with mutant carboxypeptidase E Cpe,display endocrine disorders like obesity and infertility.

• Supplier: Creative Biomart
• Product #: CPE-2891M