Dibenzazepine
Dibenzazepine, also known as YO-01027 and Iminostilbene, is a potent γ-secretase inhibitor. Dibenzazepine also potently blocks amyloid precursor protein-like (APPL) and Notch cleavage. γ-Secretase is a fascinating, multi-subunit, intramembrane cleaving protease that is now being considered as a therapeutic target for a number of diseases. Potent, orally bioavailable γ-secretase inhibitors (GSIs) have been developed and tested in humans with Alzheimer's disease (AD) and cancer.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD791 |
| CAS # | 209984-56-5 |
| Pricing | Customizable size, Inquiry |
| Synonym | YO-01027; YO 01027; YO01027; Dibenzazepine; DBZ; Iminostilbene; Deshydroxy LY-411575. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C26H23F2N3O3 |
| Exact Mass | 463.17075 |
| Molecular Weight | 463.48 |
| Elemental Analysis | C, 67.38; H, 5.00; F, 8.20; N, 9.07; O, 10.36 |
| IUPAC/Chemical Name | (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide |
| InChi Key | QSHGISMANBKLQL-OWJWWREXSA-N |
| InChi Code | InChI=1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1 |
| SMILES Code | C[C@H](NC(CC1=CC(F)=CC(F)=C1)=O)C(N[C@@H]2C(N(C)C3=CC=CC=C3C4=CC=CC=C24)=O)=O |
| Appearance | Yellow to orange solid powder. |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |