RCHY1 Antibody

• Supplier: CD BioSciences
• Product #: AMA-0472
• Product Category: Antibodies
• Application: WB, IP
• Product Usage Information Dilution: Western Blotting (1:1000); Immunoprecipitation (1:50)
• Reactivity: Human, Mouse
• Gene ID: 25898
• MW (Target): 29 kDa
• Storage: Store at -20°C. Do not aliquot the antibody.
• Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human RCHY1 protein isoform1. Antibodies are purified by protein A and peptide affinity chromatography.
• Background: RING finger and CHY1 zinc finger domain-containing protein 1 (RCHY1) is a newly identified RING-H2-type protein-ubiquitin E3 ligase that is expressed as multiple isoforms generated through alternative splicing of mRNA transcripts Notably, RCHY1 is a p53-regulated gene and multiple studies have shown that RCHY1 directly binds p53 to promote its ubiquitin-dependent proteasomal degradation, ultimately leading to repression of p53 growth suppressive transcriptional activity RCHY1 is also likely to promote deregulated cell proliferation by targeting the CDK inhibitor, p27 Kip1, for proteasomal degradation In agreement with its growth promoting activity, RCHY1 overexpression has been linked to cancer of the lung and prostate.