A‑971432
This active molecular is a selective S1P5 (Sphingosine-1-Phosphate Receptor 5) agonist originated by AbbVie for the treatment of neurodegenerative disorders. A 971432 is highly selective for S1P5 with IC50 value of 6 nM for S1P5, 362 nM for S1P1 and >10 μM for S1P3. A 971432 improves blood−brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonists have been reported as an innovative mechanism for the treatment of neurodegenerative disorders including Alzheimer's disease and lysosomal storage disorders such as Niemann-Pick disease.
| Supplier | BOC Sciences |
|---|---|
| Product # | 1240308-45-5 |
| Pricing | Inquire |
| Cas | 1240308-45-5 |
| Molecular Weight | 366.24 |
| Molecular Formula | C18H17Cl2NO3 |
| Canonical SMILES | C1C(CN1CC2=CC=C(C=C2)OCC3=CC(=C(C=C3)Cl)Cl)C(=O)O |