ALDH5A1 Antibody (NT)
Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH5A1 (aldehyde dehydrogenase 5 family, member A1), also known as SSDH or SSADH, is a 535 amino acid protein that localizes to the mitochondria and belongs to the aldehyde dehydrogenase family. Expressed in a variety of tissues, including liver, heart, lung, brain, kidney and placenta, ALDH5A1 is required for gamma-aminobutyric acid (GABA) recycling from the synaptic cleft. Mutations of ALDH5A1 lead to succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) that is characterized by severe ataxia and by mildly retarded psychomotor development.
| Supplier | Creative Biogene |
|---|---|
| Product # | PBCA1057 |
| Pricing | Inquiry |
| Isotype | Rabbit IgG |
| Research Area | Antibody |
| Antibody Target | ALDH5A1 |
| Antibody Type | Polyclonal |
| Application | WB, IHC, FACS |
| Formulation | 100 µl of antibody in PBS with 0.09% (W/V) sodium azide |
| Appearance | Liquid |
| Host | Rabbit |
| Species Reactivity | Human. |
| Usage Statement | Our products are intended for research use only and are not to be used for other purposes, including but are not limited to in vitro diagnostic uses, ex vivo or in vivo therapeutic uses. |