Aminopeptidase N Ligand (CD13), NGR peptide
It is a peptide with NGR (Asn-Gly-Arg) motif, which has a disulfide bridge linking cys1 and cys5, and is known to have antimicrobial properties in addition to the presence of KLA sequences. The peptide binds to CD13 on tumor cells and shows strong cytotoxicity and activity against tumor cells. This peptide shows dose-dependent antiproliferation against tumor cells and induces cell cylce arrest at G2/M phases and apoptosis of the tumor cells. Peptides containing the NGR motif are useful in the delivery of cytotoxic drugs, pro-apoptotic peptides, and tumor necrosis factor (TNF) into tumor vasculature.
| Supplier | BOC Sciences |
|---|---|
| Product # | BAT-013314 |
| Pricing | Inquire |
| Molecular Weight | 606.67 |
| Molecular Formula | C20H34N10O8S2 |
| Canonical SMILES | C1C(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSS1)C(=O)NCC(=O)O)CCCN=C(N)N)CC(=O)N)N |