Afuco™ Anti-Human MADCAM1 ADCC Therapeutic Antibody (PF-00547659), ADCC Enhanced
Anti-MADCAM1 ADCC Enhanced Antibody (PF-00547659) is an ADCC enhanced antibody produced by our Afuco™ platform. PF-00547659 is an anti-human MAdCAM monoclonal antibody which has potential utility in the treatment of inflammatory conditions by blocking tissue homing of activated α4β7+ leukocytes. The characterization of a rodent cross-reacting antibody as a surrogate for PF-00547659 in the search for potential pharmacological biomarkers and the determination of efficacious doses was effective in addressing the restricted orthologous cross-reactivity of PF-00547659 and the challenges this poses with respect to efficacy and safety testing.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AFC-489CL |
| Pricing | Inquiry |
| Host | Humanized |
| Target | MADCAM1 |
| Species Reactivity | Human |
| Type | ADCC enhanced antibody |
| Storage | Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |