anti-CD80 immunotoxin 6G7 (IgG)-Sap
This immunotoxin was achieved by conjugating/fusing the anti-CD80 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD80-expressing cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Hodgkin's disease or other CD80-expressing tumours.
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-L001S |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | CD80 |
| Species Reactivity | Human |