Polyethylene Glycol 6000

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Polyethylene glycol as being an addition polymer of ethylene oxide and water. Polyethylene glycol grades 200–600 are liquids; grades 1000 and above are solids at
ambient temperatures.
Liquid grades (PEG 200–600) occur as clear, colorless or slightly yellow-colored, viscous liquids. They have a slight but characteristic odor and a bitter, slightly burning taste. PEG 600 can occur as a solid at ambient temperatures.
Solid grades (PEG>1000) are white or off-white in color, and range in consistency from pastes to waxy flakes. They have a faint, sweet odor. Grades of PEG 6004 and above are available as free_x0002_flowing milled powders
Supplier CD Formulation
Product # PE-0672
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product1 Humectants Excipients
Molecular Formula HOCH2(CH2OCH2)nCH2OH, n=165~210
Applications Polyethylene glycols (PEGs) are widely used in a variety of pharmaceutical formulations, including parenteral, topical, ophthalmic, oral, and rectal preparations. Polyethylene glycol has been used experimentally in biodegradable polymeric matrices used in controlled-release systems.
Safety
  • LD50 (guinea pig, PO): 50g/kg;
  • LD50 (rat, IP): 6.8g/kg.
Incompatibilities
  • The chemical reactivity of polyethylene glycols is mainly confined to the two terminal hydroxyl groups, which can be either esterified or etherified. However, all grades can exhibit some oxidizing activity owing to the presence of peroxide impurities and secondary products formed by autoxidation.
  • Liquid and solid polyethylene glycol grades may be incompatible with some coloring agents. The antibacterial activity of certain antibiotics is reduced in polyethylene glycol bases, particularly that of penicillin and bacitracin. The preservative efficacy of the parabens may also be impaired owing to binding with polyethylene glycols.
  • Physical effects caused by polyethylene glycol bases include softening and liquefaction in mixtures with phenol, tannic acid, and salicylic acid. Discoloration of sulfonamides and dithranol can also occur, and sorbitol may be precipitated from mixtures. Plastics, such as polyethylene, phenolformaldehyde, polyvinyl chloride, and cellulose-ester membranes (in filters) may be softened or dissolved by polyethylene glycols. Migration of polyethylene glycol can occur from tablet film coatings, leading to interaction with core components.
Synonyms Macrogol 6000
CAS Number 25322-68-3
Category Plasticizer; slip agent; solvent; base agent; binder; suspending agent; gloss agent; coating agent; wetting agent; sugar-coating agent; adhesion enhancer; viscous agent; excipient; dispersant; detoxifier; dehumidifier
UNII 30IQX730WE
Chemical Name Polyethylene Glycol 6000
Grade Pharmaceutical grade
Administration route Oral; Sublingual; Rectal; Vaginal
Dosage Form Tablets (including sustained and controlled release, etc.), capsules, suppositories, creams, inserts
Stability and Storage Conditions Sealed and stored in a dry place.
Commonly used amount and the maximum amount The maximum dosage of each route of administration: oral: 750mg; rectum, cavity, urethra: 4.05g; general topical preparations: 75mg/g; transdermal: 308.8mg; sublingual administration: 80mg/g; ophthalmic medication: 5mg/g ; Dental external preparations and oral medicine: 250mg.
Source and Preparation Polyethylene glycol polymers are formed by the reaction of ethylene oxide and water under pressure in the presence of a catalyst.
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