| Supplier |
Creative Peptides |
| Product # |
R1220 |
| CAS # |
1337878-62-2 |
| Pricing |
Inquire
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| MolecularFormula |
C104H178N26O25S2
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| MolecularWeight |
2256.82
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| Sequence |
- One Letter Code: 1-Oxohexadecyl-MGYQKKLRSMTDKYRL
- Three Letter Code: 1-Oxohexadecyl-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu
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| Storage |
Desiccate at -20°C
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| ShippingCondition |
Room temperature in continental US; may vary elsewhere.
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| Explanation |
ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs).
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| Solubility |
Soluble to 1 mg/ml in water
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| BiologicalActivity |
CXCR4 allosteric agonist (EC50 = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards Gi proteins over G13 and β-arrestin.
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