Ceratonia
Ceratonia occurs as a yellow-green or white colored powder. Although odorless and tasteless in the dry powder form, ceratonia acquires a leguminous taste when boiled in water.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0468 |
| Pricing | , Inquire for price |
| product1 | Binder Excipients |
| Applications | Ceratonia is a naturally occurring material generally used as a substitute for tragacanth or other similar gums. A ceratonia mucilage that is slightly more viscous than tragacanth mucilage may be prepared by boiling 1.0-1.5% of powdered ceratonia with water. As a viscosity-increasing agent, ceratonia is said to be five times as effective as starch and twice as effective as tragacanth. Ceratonia has also been used as a tablet binder and is used in oral controlled-release drug delivery systems approved in Europe and the USA. Ceratonia is widely used as a binder, thickening agent, and stabilizing agent in the cosmetics and food industry. In foods, 0.15-0.75% is used. Therapeutically, ceratonia mucilage is used orally in adults and children to regulate intestinal function. |
| Safety | Ceratonia is generally regarded as an essentially noncarcinogenic, nontoxic and nonirritant material. Therapeutically, it has been used in oral formulations for the control of vomiting and diarrhea in adults and children; 20-40 g daily in adults has been used dispersed in liquid. As an excipient, ceratonia is used in oral controlledrelease formulations approved in Europe and the USA. Ceratonia is also widely used in food products. The WHO has not specified an acceptable total daily intake for ceratonia as the total daily intake arising from its use at the levels necessary to achieve the desired effect, and from its acceptable background in food, was not considered to represent a hazard to health.Ceratonia hypersensitivity has been reported, in a single case report, in an infant. However, ceratonia is said to be nonallergenic in children with known allergy to peanuts. LD50 (hamster, oral): 10.0 g/kg LD50 (mouse, oral): 13.0 g/kg LD50 (rabbit, oral): 9.1 g/kg LD50 (rat, oral): 13.0 g/kg |
| Incompatibilities | The viscosity of xanthan gum solutions is increased in the presence of ceratonia. This interaction is used synergistically in controlledrelease drug delivery systems. |
| Synonyms | Algaroba; carob bean gum; carob flour; ceratonia gum; ceratonia siliqua; ceratonia siliqua gum; Cheshire gum; E410; gomme de caroube; locust bean gum; Meyprofleur; St John’s bread |
| CAS Number | 9000-40-2 |
| Category | Controlled-release Agents; Stabilizing Agents; Suspending Agents; Tablet Binder; Viscosity-increasing Agents |
| UNII | V4716MY704 |
| Chemical Name | Carob gum |
| Grade | Pharmceutical Excipients |
| Administration route | Oral |
| Dosage Form | oral tablet |
| Stability and Storage Conditions | The bulk material should be stored in a well-closed container in a cool, dry place. Ceratonia loses not more than 15% of its weight on drying. |
| Source and Preparation | Ceratonia is a naturally occurring material obtained from the ground endosperms separated from the seeds of the locust bean tree, Ceratonia siliqua (Leguminosae). The tree is indigenous to southern Europe and the Mediterranean region. |