Tyk2-IN-5
Tyk2-IN-5 is a selective, highly potent and orally active Tyk2 inhibitor targeting the JH2 domain with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. It can effectively inhibit IFNγ production in a rat pharmacodynamics model, and is completely effective in a rat adjuvant arthritis model.
| Supplier | BOC Sciences |
|---|---|
| Product # | 1797432-62-2 |
| Pricing | Inquire |
| Cas | 1797432-62-2 |
| Molecular Weight | 434.43 |
| Molecular Formula | C21H19FN8O2 |
| Canonical SMILES | CNC1=CC(=NN2C1=NC=C2C(=O)NC3CC3F)NC4=CC=CN(C4=O)C5=CC=CC=N5 |