Human Anti-HIV-1 gp120 Recombinant Antibody (clone MAb 2158); scFv Fragment
This is a anti-gp120 monoclonal antibody (MAb) 2158, which targets a conformational V2 epitope overlapping the 47 integrin binding site, and constructed a full-length model of V1V2. MAb 2158 was isolated from a subtype B virusinfected subject and is broadly cross-reactive and capable of neutralizing many tier 1 viruses. However, it does not neutralize tier 2 viruses, even though it can bind quite a few tier 2 gp120s; an increased length of V2 and increased total number of glycosylation sites within the hypervariable region are possibilities for the discordance between 2158 binding and neutralization.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-S0052-YC-S(P) |
| Pricing | Inquiry |
| Host | Human |
| Target | HIV-1 gp120 |
| Species Reactivity | HIV-1 |
| Type | Human scFv |
| Applications | ELISA, Neut |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |