Hydroxypropyl Betadex
Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0341 |
| Pricing | , Inquire for price |
| product1 | Excipients |
| Molecular Formula | C42H70O35(C3H6O)x |
| Applications | Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids, oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations. Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials.The reported advantage of hydroxypropyl betadex over unsubstituted β -cyclodextrin is its greater water solubility. |
| Safety | The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability. |
| Synonyms | Cavasol W7; 2-hydroxypropyl-b-cyclodextrin; 2-hydroxypropyl cyclomaltoheptaose; hidroksipropilbetadeksas; hydoxipropylbeta- dex; hydroksipropylbetadeksi; hydroxypropylbetadeksum; hydro- xypropylbetadexum; Kleptose HPB |
| CAS Number | 128446-35-5 |
| Category | Solubilizing Agents; Stabilizing Agents |
| UNII | 1I96OHX6EK |
| Chemical Name | β-Cyclodextrin, 2-hydroxypropyl ether |
| Grade | Pharmceutical Excipients |
| Administration route | Injectable |
| Dosage Form | Injectable preparation |
| Stability and Storage Conditions | Store in well-closed containers. |
| Source and Preparation | Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of β-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography. |