Avatrombopag hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-13463B-10 mg |
| CAS # | 570403-17-7 |
| Pricing | 10 mg, USD $600.0 |
| Synonyms | AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride |
| MWt | 686.12 |
| Formula | C₂₉H₃₅Cl₃N₆O₃S₂ |
| Biological Activity | Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3]. |
| Purity | 98.05% |