Monosodium Glutamate
Monosodium glutamate occurs as white free-flowing crystals or a crystalline powder. It is practically odorless and has a meat-like taste.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0422 |
| Pricing | , Inquire for price |
| product1 | Pharmaceutical Excipients |
| Molecular Formula | C5H8NO4Na; C5H8NO4Na·H2O |
| Molecular Weight | 169.13(anhydrous); 187.13 (monohydrate) |
| Applications | Monosodium glutamate is used in oral pharmaceutical formulations as a buffer and a flavor enhancer. For example, it is used with sugar to improve the palatability of bitter-tasting drugs and can reduce the metallic taste of iron-containing liquids. It has also been used in subcutaneous live vaccine injections such as measles, mumps, rubella and varicella-zoster live vaccine. However, the most widespread use of monosodium glutamate is as a flavor enhancer in food products. Typically, 0.2-0.9% is used in normally salted foods, although products such as soy protein can contain 10-30%. The use of monosodium glutamate in food products has been controversial owing to the apparently high number of adverse reactions attributed to the substance, which gives rise to the so-called‘Chinese Restaurant Syndrome'. |
| Safety | Monosodium glutamate is widely used in foods and oral pharmaceutical formulations. It is generally regarded as moderately toxic on ingestion or intravenous administration. Adverse effects include somnolence, hallucinations and distorted perceptions, headache, dyspnea, nausea or vomiting, and dermatitis. The lowest lethal oral dose in humans is reported to be 43 mg/kg. |
| Incompatibilities | / |
| Synonyms | Chinese seasoning; glutamic acid monosodium salt; glutamic acid, sodium salt; monosodium L-glutamate monohydrate; natrii glutamas; sodium L-glutamate; sodium glutamate monohydrate; sodium hydrogen L-(þ)-2-aminoglutarate monohydrate. |
| CAS Number | 142-47-2 |
| Category | Flavoring agent |
| UNII | W81N5U6R6U |
| Chemical Name | Glutamic acid monosodium salt monohydrate |
| Grade | Pharmceutical Excipients |
| Administration route | Oral |
| Dosage Form | Oral syrup |
| Stability and Storage Conditions | Aqueous solutions of monosodium glutamate may be sterilized by autoclaving. Monosodium glutamate should be stored in a tight container in a cool, dry place. |
| Source and Preparation | Monosodium glutamate is the monosodium salt of the naturally occurring L-form of glutamic acid. It is commonly manufactured by fermentation of carbohydrate sources such as sugar beet molasses.In general, sugar beet products are used in Europe and the USA. Other carbohydrate sources such as sugar cane and tapioca are used in Asia. |