L-685458

Supplier MedChemExpress
Product # HY-19369-10 mM * 1 mL
CAS # 292632-98-5
Pricing 10 mM * 1 mL, USD $782.0
Synonyms L-685,458
MWt 672.85
Formula C₃₉H₅₂N₄O₆
Biological Activity L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers[1][2].
Purity 99.78%
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