VU 0650786
VU 0650786 is a mGlu3 negative allosteric modulator. VU 0650786 has an mGlu2 IC50 of greater than 30 uM and mGlu3 IC50 of 392 nM, suggesting that it is highly selective for mGlu2 and mGlu3.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1257 |
| CAS # | NONE |
| Pricing | Customizable size, Inquiry |
| Synonym | VU 0650786; VU-0650786; VU0650786 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H15ClFN5O2 |
| Exact Mass | 387.0898 |
| Molecular Weight | 387.8 |
| Elemental Analysis | C, 55.75; H, 3.90; Cl, 9.14; F, 4.90; N, 18.06; O, 8.25 |
| IUPAC/Chemical Name | (R)-2-(((5-chloropyridin-2-yl)oxy)methyl)-5-(2-fluoropyridin-3-yl)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one |
| InChi Key | RXRVCJFGSOVYLG-LLVKDONJSA-N |
| InChi Code | InChI=1S/C18H15ClFN5O2/c1-11-9-24(14-3-2-6-21-17(14)20)18(26)15-7-13(23-25(11)15)10-27-16-5-4-12(19)8-22-16/h2-8,11H,9-10H2,1H3/t11-/m1/s1 |
| SMILES Code | ClC1=CC=C(OCC2=NN([C@H](C)CN(C3=C(F)N=CC=C3)C4=O)C4=C2)N=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |