PROTAC Mcl1 degrader-1
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-125877-5 mg |
| CAS # | 2163793-38-0 |
| Pricing | 5 mg, USD $980.0 |
| Biological Activity | PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity[1]. |
| Purity | 98.13% |
| MWt | 909.84 |
| Formula | C₄₅H₄₅BrN₆O₈S |