| Supplier |
CD BioSciences |
| Product # |
AMA-0627 |
| Pricing |
100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB
|
| Product Usage Information Dilution |
Western Blotting (1:1000)
|
| Reactivity |
Human, Mouse, Rat, Monkey
|
| Host |
Rabbit
|
| Gene ID |
60673
|
| UniProt ID |
|
| Source/Isotype |
Rabbit IgG
|
| MW (Target) |
25 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val177 of human Atg101 protein.
|
| Background |
Atg101 was discovered as a binding protein for Atg13, a component of the ULK1 serine-threonine kinase complex required for autophagy Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents It is generally activated by conditions of nutrient deprivation, but is also associated with a number of physiological processes, including development, differentiation, neurodegeneration, infection, and cancer The molecular machinery of autophagy was largely discovered in yeast and is directed by a number of autophagy-related (Atg) genes. The ULK1 complex includes both Atg13 and FIP200 and is required for starvation-induced autophagy Interaction between Atg101 and Atg13 can be important for the stability and basal phosphorylation of Atg13 and ULK1.
|