LAMP-1 Antibody

Supplier CD BioSciences
Product # AMA-0215
Pricing 100 µg, Inquire
Product Category Antibodies
Application WB, IHC, ELISA
Product Usage Information Dilution Western Blotting (1-2 μg/mL); Immunofluorescence (20 μg/mL)
Reactivity Human, Mouse, Rat
Host Rabbit
Gene ID 3916
Source/Isotype Rabbit IgG1
Storage Store at -20°C.
Purification Affinity chromatography purified via peptide column.
Background Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is thoμght to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, sμggesting that each protein possesses some unique and necessary functions.
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