Recombinant Human TAK1-TAB1 (N-GST tag)

TAK1 is a serine/threonine protein kinase that mediates signaling by TGF汕 and morphogenetic protein (BMP). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (Nf?B). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8. Thymocytes lacking TAK1 fail to activate Nf?B and JNK and are prone to apoptosis upon stimulation.

• Supplier: Amerigo Scientific
• Product #: Z500378