lipoate-protein ligase
Requires Mg2+. This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid. The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein). Lipoylation is essential for the function of these enzymes. The enzyme can also use octanoate instead of lipoate.
| Supplier | Creative Enzymes |
|---|---|
| Product # | EXWM-5723 |
| Pricing | 100 ug, contact supplier for pricing |
| CAS | 144114-18-1 |