Saredutant
Saredutant, aslo known as SR-48968, is a NK2 receptor antagonist for the treatment of major depressive disorder. Saredutant has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant, ameliorates stress-induced conditions without impairing cognition. SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex. SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1139 |
| CAS # | 142001-63-6 |
| Pricing | Customizable size, Inquiry |
| Synonym | SR-48968; SR489686; SR 489686; Saredutant |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C31H35Cl2N3O2 |
| Exact Mass | 551.2106 |
| Molecular Weight | 552.54 |
| Elemental Analysis | C, 67.39; H, 6.39; Cl, 12.83; N, 7.61; O, 5.79 |
| IUPAC/Chemical Name | (S)-N-(4-(4-acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl)-N-methylbenzamide |
| InChi Key | PGKXDIMONUAMFR-AREMUKBSSA-N |
| InChi Code | InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1 |
| SMILES Code | O=C(N(C[C@@H](CCN1CCC(C2=CC=CC=C2)(NC(C)=O)CC1)C3=CC=C(Cl)C(Cl)=C3)C)C4=CC=CC=C4 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |