PF-04859989
PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II). PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1658 |
| CAS # | 34783-48-7 (free base) |
| Pricing | Customizable size, Inquiry |
| Synonym | PF-04859989; PF 04859989; PF04859989; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C9H10N2O2 |
| Exact Mass | 178.0742 |
| Molecular Weight | 178.19 |
| Elemental Analysis | C, 60.66; H, 5.66; N, 15.72; O, 17.96 |
| IUPAC/Chemical Name | (S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one |
| InChi Key | HYTRYTZFJVVZAF-ZETCQYMHSA-N |
| InChi Code | InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1 |
| SMILES Code | ON(C1=CC=CC=C1C[C@@H]2N)C2=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |