B-Cell Linker Protein (BLNK) Antibody

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Supplier: Abbexa Ltd.
• Product #: abx011968-100UL
• Clonality: Monoclonal
• Conjugation: Unconjugated
• Host: Mouse
• Tested Applications: ELISA, WB, IHC, IF/ICC, FCM
• UniProt Primary AC: Q8WV28
• Dry Ice: No
• Availability: Shipped within 5-10 working days.
• Note: This product is for research use only.