BMS-181100 HCl
BMS-181100, also known as BMY-14802; BMY-14802-1, is a sigma receptor antagonist and a 5-HT1A agonist with antipsychotic effects and potential useful for the treatment of schizophrenia. BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats. BMY 14802 prevents methamphetamine-induced dopaminergic neurotoxicity via interactions at dopamine receptors. BMY-14802 reverses amphetamine-induced changes in neostriatal single-unit activity in freely moving rats. BMY 14802 increases expression of proneurotensin mRNA in the rat striatum.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1409 |
| CAS # | 105565-55-7 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | BMS-181100; BMS181100; BMS181100; BMY-14802; BMY 14802; BMY14802; BMY-14802-1; BMS-181100 HCl; BMS-181100 hydrochloride. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H23ClF2N4O |
| Molecular Weight | 384.8558 |
| Elemental Analysis | C, 56.18; H, 6.02; Cl, 9.21; F, 9.87; N, 14.56; O, 4.16 |
| IUPAC/Chemical Name | 1-(4-fluorophenyl)-4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)butan-1-ol hydrochloride |
| InChi Key | NIBVEFRJDFVQLM-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C18H22F2N4O.ClH/c19-15-5-3-14(4-6-15)17(25)2-1-7-23-8-10-24(11-9-23)18-21-12-16(20)13-22-18;/h3-6,12-13,17,25H,1-2,7-11H2;1H |
| SMILES Code | OC(C1=CC=C(F)C=C1)CCCN2CCN(C3=NC=C(F)C=N3)CC2.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |