UR-13870
UR-13870 is a p38 mitogen-activated protein kinase (MAPK) inhibitor potentially for the treatment of autoimmune disease and neuropathic pain. UR-13870 treatment significantly reduced OX-42, metabotropic glutamate type 5 receptor (mGluR5), and NMDA (N-methyl-d-aspartate) 2B subunit receptor (NR2B) expression in the anterior cingulate cortex after spinal cord injury. UR-13870 treatment significantly decreased hindlimb hyperreflexia to both mechanical and cold stimuli after spared nerve injury without loss of general motor function, in addition to a reduction in pain-related anxiety behavior at day 21 after spared nerve injury, accompanied by normalization of OX-42 immunoreactivity within the ipsilateral lumbar dorsal horn.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD438 |
| CAS # | 755753-89-0 |
| Pricing | Customizable size, Inquiry |
| Synonym | UR-13870, UR 13870, UR13870 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C24H16F2N4 |
| Exact Mass | 398.1343 |
| Molecular Weight | 398.4168 |
| Elemental Analysis | C, 72.35; H, 4.05; F, 9.54; N, 14.06 |
| IUPAC/Chemical Name | 4,6-bis(4-fluorophenyl)-2-methyl-5-(pyridin-4-yl)-2H-pyrazolo[3,4-b]pyridine |
| InChi Key | VMAKTIDYMSNPOV-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C24H16F2N4/c1-30-14-20-21(15-2-6-18(25)7-3-15)22(16-10-12-27-13-11-16)23(28-24(20)29-30)17-4-8-19(26)9-5-17/h2-14H,1H3 |
| SMILES Code | CN1N=C2C(C(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)C(C5=CC=C(F)C=C5)=N2)=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |