Recombinant Humanized Anti-Pertussis toxin Antibody (hu1B7-YTE)
To extend the plasma half-life of the hu1B7 antibody, three amino acid changes were introduced into the CH2 domain of the human IgGl Fc region. These changes, M252Y/S254T/T256E, referred to as YTE, function to increase the antibody's affinity for the neonatal Fc receptor, but only at the low, endosomal pH. Thus, when the antibody is taken up by this receptor, it is not released in the endosome and is recycled to the cell surface where it is released back into circulation. The YTE changes may also reduce binding to several Fey receptors, in particular FcyRIII. HulB7-YTE extended half-life antibody was generated via transient expression in CHO cells.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-N0229-YC |
| Pricing | Inquiry |
| Host | Human |
| Target | Pertussis toxin |
| Species Reactivity | B. pertussis |
| Type | Humanized IgG1 |
| Applications | ELISA |