Daporinad, Free Base (APO866, FK866, K22.175, WK175, CAS 658084-64-1), >99%

LC Laboratories' Product Number D-5600 - Daporinad, Free Base (APO866, FK866, K22.175, WK175, CAS 658084-64-1), >99% - for research use only. Daporinad, also known as FK-866, is a highly specific, noncompetitive inhibitor of nicotinamide phosphoribosyltransferase (NAPRT) with Ki values of 0.4 nM for the enzyme/substrate complex and 0.3 nM for the free enzyme, respectively. NAPRT is a key enzyme in the regulation of NAD+ biosynthesis from the natural precursor nicotinamide. Daporinad initiated apoptosis by gradual depletion of the intracellular coenzyme NAD+. This research compound is the free base form of daporinad. We also soon be offering the hydrochloride salt form Daporinad, Hydrochloride Salt, Cat. No. D-5644. Daporinad was capable of reducing the secondary inflammatory injury and partly reducing permanent damage after spinal cord injury. NAPRT protein levels were increased upon spinal cord injury in the perilesional area, which was corrected by daporinad. Reciprocal potentiation of the antitumor activities of daporinad and etoposide or cisplatin was observed in neuroblastoma cells. This daporinad product is the free base, whohas two different CAS numbers: 201034-75-5 and 658084-64-1. As of May 18, 2016, no CAS number had been reported for the hydrochloride salt. Another CAS number previously assigned to Daporinad, namely 1198425-96-5, has been deleted by CAS and is no longer in use.

• Supplier: LC Laboratories
• Product #: D-5600
• Sku #: D-5600_50mg