Plinabulin-[13C6]
Labelled Plinabulin. Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 value of 9.8~18 nM in tumor cells under the development of Nereus Pharmaceuticals. It can bind to the colchicine binding site of b-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. In Sep 2016, BeyondSpring Pharmaceuticals planed a phase II/III trial for Neutropenia. Phase I clinical trials for Solid tumours and Phase III clinical trials for Non-small cell lung cancer are on-going.
| Supplier | BOC Sciences |
|---|---|
| Product # | BLP-001388 |
| Pricing | Inquire |
| Molecular Weight | 342.34 |
| Molecular Formula | C13[13C]6H20N4O2 |