Diphenidol-d10
Diphenidol-d10 is intended for use as an internal standard for the quantification of diphenidol by GC- or LC-MS. Diphenidol is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.43, 2.8, 1.1, 0.91, and 1.28 µM in CHO cell membranes expressing M1-5 receptors, respectively). It also inhibits Kv channels in Neuro2A cells (IC50 = 28.2 µM), as well as L-type voltage-gated calcium channels in differentiated NG 108-15 cells in a concentration-dependent manner. Microiontophoretic application of diphenidol inhibits rotation-induced firing of medial vestibular nucleus neurons in a cat model of vertigo. Diphenidol (3.2 mg/kg, i.v.) prevents apomorphine-induced emesis in dogs. Formulations containing diphenidol have been used in the treatment of vertigo and as antiemetics.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD182 |
| CAS # | unknown |
| Pricing | Customizable size, Inquiry |
| Synonym | Diphenidol-d10; Diphenidol d10; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H17D10NO |
| Exact Mass | 319.272 |
| Molecular Weight | 319.514 |
| Elemental Analysis | C, 78.94; H, 11.67; N, 4.38; O, 5.01 |
| IUPAC/Chemical Name | 1,1-diphenyl-4-(piperidin-1-yl-d10)butan-1-ol |
| InChi Key | OGAKLTJNUQRZJU-FNJHSXSFSA-N |
| InChi Code | InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2/i3D2,8D2,9D2,16D2,17D2 |
| SMILES Code | OC(CCCN1C([2H])(C([2H])(C([2H])(C([2H])(C1([2H])[2H])[2H])[2H])[2H])[2H])(C2=CC=CC=C2)C3=CC=CC=C3 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |