Recombinant Human Anti-HIV-1 gp120 Antibody (45-46M2)
Recombinant Human Antibody (45-46M2) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp120 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-HIV-1 gp120 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. Antibodie 45-46m2 targeting only two epitopes, can control viremia in vivo; thus, this combination of bNAbs was able to suppress both the parental viral YU-2 viral strain and N/DNGG consensus-based escape mutants.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABZ-169 |
| Pricing | Inquiry |
| Host | Human |
| Target | HIV-1 gp120 |
| Species Reactivity | HIV-1 |
| Type | IgG |
| Applications |
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| Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples. |