KU-55933 (ATM Kinase Inhibitor, CAS 587871-26-9), >99%

LC Laboratories' Product Number K-5050 - KU-55933 (ATM Kinase Inhibitor, CAS 587871-26-9), >99% - for research use only. KU 55933 is an inhibitor of the oncosuppressor protein ataxia telangiectasia mutated (ATM) kinase. It inhibited ATM with an IC50 of 13 nM and a Ki of 2.2 nM. KU-55933 significantly sensitized Hela cells to the cytotoxic effects of ionizing radiation and chemotherapeutic agents including etoposide (please see Cat. No. E-4488, Etoposide and Cat. No. E-4444, Etoposide 4'-Phosphate, Free Acid), amsacrine, doxorubicin (please see Cat. No. D-4000, Doxorubicin, Hydrochloride Salt and Cat. No. D-4099, Doxorubicin, Free Base), and camptothecin. Blocking ATM/ATR (ATM- and Rad3-related) signaling with KU55933 induced senescent breast, lung, and colon carcinoma cells to undergo cell death via targeting p21CIP1. KU-55933 blocked the phosphorylation of Akt induced by insulin and insulin-like growth factor I, inhibited cancer cell proliferation by inducing G1 cell cycle arrest, and triggered apoptosis during serum starvation in cancer cells. A combination of KU-55933 and rapamycin (please see Cat. No. R-5000, Rapamycin) induced apoptosis and showed better efficacy in inhibiting the growth of cancer cells than each drug alone. KU-55933 suppressed the syncytial apoptosis induced either by wild type HIV-1 or by an HIV-1 mutant lacking integrase activity. KU-55933 suppressed the replication of both wild-type and drug-resistant HIV-1.

• Supplier: LC Laboratories
• Product #: K-5050
• Sku #: K-5050_5mg