p16 INK4A (D3W8G) Rabbit Antibody

• Supplier: CD BioSciences
• Product #: AMA-0161
• Product Category: Antibodies
• Application: WB, IP
• Product Usage Information Dilution: Western Blotting (1:1000); Immunoprecipitation (1:50)
• Reactivity: Human
• Host: Rabbit
• Source/Isotype: Rabbit IgG
• MW (Target): 16 kDa
• Storage: Store at -20°C.
• Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala34 of human p16 INK4A protein.
• Background:
  • Members of the INK4 family of cyclin dependent kinase inhibitors include p16 INK4A, p15 INK4B, p18 INK4C, and p19 INK4D. The INK4 family members inhibit cyclin dependent kinases 4 and 6 (CDK4 and CDK6), causing cell cycle arrest in G1 phase. The INK4A-ARF-INK4B locus on chromosome 9p21, frequently lost in human cancer, encodes the INK4 family members p16 INK5A and p15 INK4B, as well as the unrelated protein, ARF.
  • p16 INK4A expression, typically repressed in the absence of stress, is thought to drive cells into senescence, and p16 INK4A expression is a commonly used marker of senescent cells. p16 INK4A protein expression is often altered in human cancer, and high expression is currently used as a predictive biomarker in cervical cancer.