Emapunil
Emapunil, also known as AC-5216 and XBD-173, is a novel mitochondrial benzodiazepine receptor ligand (MBR ligand). AC-5216 showed high affinity for MBRs prepared from rat whole brain (Ki 0.297 nm), rat glioma cells (IC50 3.04 nm) and human glioma cells (IC50 2.73 nm), but only negligible affinity for the other main receptors including central benzodiazepine receptors. AC-5216 produced anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice at 0.1-3, 0.003-0.01 and 0.01-0.3 mg kg(-1), p.o., respectively.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD156 |
| CAS # | 226954-04-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | AC-5216; AC 5216; AC5216; XBD-173; XBD 173; XBD173; Emapunil. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C23H23N5O2 |
| Exact Mass | 401.1852 |
| Molecular Weight | 401.47 |
| Elemental Analysis | C, 68.81; H, 5.77; N, 17.44; O, 7.97 |
| IUPAC/Chemical Name | N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide |
| InChi Key | NBMBIEOUVBHEBM-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C23H23N5O2/c1-3-27(15-17-10-6-4-7-11-17)20(29)16-28-22-19(26(2)23(28)30)14-24-21(25-22)18-12-8-5-9-13-18/h4-14H,3,15-16H2,1-2H3 |
| SMILES Code | O=C(N(CC)CC1=CC=CC=C1)CN2C(N(C)C3=CN=C(C4=CC=CC=C4)N=C23)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Depression |
| Availability | 2 Weeks |