Anti-Human IGF2 Therapeutic Antibody (DX-2647)
Recombinant Human monoclonal antibody expressed in CHO binding to Human IGF2. This is a human monoclonal antibody against insulin-like growth factor-II that blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. DX-2647 inhibited IGF-II and, to a lesser extent, IGF-I-induced receptor tyrosine phosphorylation, cellular proliferation, and both anchorage-dependent and anchorage-independent colony formation in various cell lines. In addition, DX-2647 slowed tumor progression in the Hep3B xenograft model, causing decreased tumoral CD31 staining as well as reduced IGF-IIE and IGF-IR phosphorylation levels. Therefore, DX-2647 offers an alternative approach to targeting IGF-IR, blocking IGF-II signaling through both IGF-IR and IR-A.
Supplier | Creative Biolabs |
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Product # | TAB-387CL |
Pricing | Inquiry |
Host | Human |
Target | IGF2 |
Species Reactivity | Human |
Type | Antibody |
Applications | BL, Inhib |
Storage | Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C. |