Purvalanol A
Purvalanol A is a potent CDK inhibitor that potently inhibits Src-mediated transformation by inhibiting CDK and c-Src. Activation of CDKs was shown to contribute to c-Src conversion. Purvalanol A inhibits c-Src activity as effectively as the Src-selective inhibitor PP2, and it restores transformed morphology to an almost normal shape with less cytotoxicity than PP2. Purvalanol A induces a strong G2-M block, whereas PP2 has a weak effect on the G1-S transition.
| Supplier | Alfa Cytology |
|---|---|
| Product # | BC0110 |
| Pricing | 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 500.0 mg, 1.0 g, inquire |