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Poly(lactide-alt-glycolide) contains alternating sequence of lactide and clycolide in the polymer chain, unlike Poly(lactide-co-glycolide) (PLGA). The molar ratio of lactic to glycolic units in the polymer is exactly 1:1. Poly(lactide-alt-glycolide) has improved solutibilty in a broad range of organic solvents such as acetonitrile, acetone, dioxane, DCM and THF, providing great convenience for drug delivery researches and applications. Traditional PLGA polymers have a random distribution of glycolide and lactide units which impacts solutibilty. Compared to random PLGA with LA:GA ratios of 50/50, alternative PLGA undergoes hydrolysis in vivo with minimal changes in pH and a lower amount of acidic by-products.
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