Sorbitan Monostearate
Cream solid
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0535 |
| Pricing | , Inquire for price |
| product1 | Surfactant Excipients |
| Molecular Formula | C24H46O6 |
| Molecular Weight | 431.0 |
| Applications | Emulsifiers; nonionic surfactants; solubilizers; wetting agents and dispersing/suspending agents. As a lipophilic nonionic surfactant, sorbitan ester is widely used in cosmetics, food and pharmaceuticals. They are primarily used as emulsifiers in the preparation of creams, emulsions and ointments for topical application. When used alone, sorbitan ester can prepare stable water-in-oil emulsions and microemulsions, but if it is used in combination with polysorbate esters in different proportions, various water-in-oil or oil-in-water emulsions or cream. |
| Safety | Sorbitan ester is widely used in cosmetics, food, oral and topical pharmaceutical preparations, and is generally considered non-toxic and non-irritating. However, there have been occasional reports of allergic skin reactions to topical agents containing sorbitan cilexetil. Sorbitan ester emits irritating fumes when heated to decomposition temperature. The WHO has determined the acceptable daily intake for humans of sorbitan monopalm, sorbitan monostearate, sorbitan tristearate, sorbitan monolaurate and sorbitan monooleate: 25 mg per kg body weight (based on total sorbitan esters) . Sorbitan monostearate: LD50 (rat, oral): 31g/kg. Moderate ingestion toxicity. Has experimental reproductive effects. |
| Synonyms | Ablunol S-60; Alkamuls SMS; 1, 4-Anhydro-D-glucitol, 6-octadecanoate; anhydrosorbitol monostearate; Arlacel 60; Armotan MS; Atlas 110K; Capmul S; Crill 3; Dehymuls SMS; Drewmulse SMS; Drewsorb 60K; Durtan 6O; Durtan 60K; E491; Famodan MS Kosher; Glycomul S FG; Glycomul S KFG; Hodag SMS; Lamesorb SMS; Liposorb S; Liposorb SC; Liposorb S-K; Montane 60; Nissan Nonion SP-60R; Norfox Sorbo S-60FG; Polycon S60K; Protachem SMS; Prote-sorb SMS; S-Maz 60K; SMaz 60KHS; Sorbester P18; Sorbirol S; sorbitan stearate; sorbitani stearas; Sorgen 50; Span 60; Span 60K; Span 60 VS; Tego SMS |
| CAS Number | 1338-41-6 |
| Category | Dispersing Agents; Emulsifying Agents; Nonionic Surfactant; solubilizing Agents; Suspending Agents; Wetting Agents |
| UNII | NVZ4I0H58X |
| Chemical Name | Sorbitan mono-octadecanoate |
| Grade | Pharmceutical Excipients |
| Administration route | Administration of topical preparations, sublingual administration, rectal cavity urethral administration, dental external application and tablet use. |
| Dosage Form | Inhalation, intramuscular, ophthalmic, oral, topical and vaginal formulations |
| Stability and Storage Conditions | Gradually saponified under strong acid or strong base; stable in weak acid or weak base. Sorbitan ethoxylate should be packed in airtight containers and stored in a cool, dry place. |
| Source and Preparation | Sorbitol is dehydrated to 1, 4-Sorbitan, and then obtained by esterification with stearic acid. |