Talazoparib-[13C,d4]
Labelled analogue of Talazoparib. Talazoparib, also known as BMN-673, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.
| Supplier | BOC Sciences |
|---|---|
| Product # | BLP-004523 |
| Pricing | Inquire |
| Molecular Weight | 385.37 |
| Molecular Formula | C18[13C]H10D4F2N6O |
| Canonical SMILES | CN1C(=NC=N1)C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F |