Actinomycin D (Dactinomycin)
Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S8964 |
| Sku # | S8964-50mg |
| Pricing | 50mg, $599.00 |
Citations for this product:
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RNA-binding protein YBX1 promotes Type H vessels dependent bone formation in an m5C-dependent mannerbioRxiv - Molecular Biology 2023Quote: ... the cells were treated with 5 μg/ml actinomycin D (S8964, Selleck Chemicals) or DMSO and collected at the indicated time points ...