Jak1 Antibody
| Supplier | CD BioSciences |
|---|---|
| Product # | AMA-0453 |
| Pricing | 100 µL, Inquire |
| Product Category | Antibodies |
| Application | WB |
| Product Usage Information Dilution | Western Blotting (1:1000) |
| Reactivity | Human, Mouse |
| Gene ID | 3716 |
| UniProt ID | |
| MW (Target) | 130 kDa |
| Storage | Store at -20°C. Do not aliquot the antibody. |
| Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr1022/1023 of human Jak1. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats Shc insulin receptor substrates and focal adhesion kinase (FAK) typically contain SH2 or other phospho-tyrosine-binding domains. |