Loxapine-d8
Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine by GC- or LC-MS. Loxapine is an atypical antipsychotic. It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to α1A-, α2A-, α2B-, and α2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD583 |
| CAS # | 1189455-63-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | Loxapine-d8; Loxapine d8; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H10D8ClN3O |
| Exact Mass | 335.1641 |
| Molecular Weight | 335.8608 |
| Elemental Analysis | C, 64.37; H, 7.80; Cl, 10.55; N, 12.51; O, 4.76 |
| IUPAC/Chemical Name | 2-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)dibenzo[b,f][1,4]oxazepine |
| InChi Key | XJGVXQDUIWGIRW-JNJBWJDISA-N |
| InChi Code | InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3/i8D2,9D2,10D2,11D2 |
| SMILES Code | ClC1=CC2=C(OC3=C(N=C2N4C([2H])(C([2H])(N(C([2H])(C4([2H])[2H])[2H])C)[2H])[2H])C=CC=C3)C=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Schizophrenia |
| Availability | 2 Weeks |