anti-NCAM1 immunotoxin N901 (IgG)-PAP
This immunotoxin was achieved by conjugating/fusing the Anti-NCAM1 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to small-cell lung cancer (SCLC) cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of small-cell lung cancer (SCLC).
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-L037P |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | NCAM1 |
| Species Reactivity | Human |