Anti-GOLPH3 Antibody
Golgi phosphoprotein 3 (UniProt Q9H4A6; also known as Coat protein GPP34, MIDAS, Mitochondrial DNA absence factor) is encoded by the GOLPH3 (also known as GPP34) gene (Gene ID 64083) in human. GOLPH3 is a phosphatidylinositol 4-phosphate- (PI4P-) binding protein that plays an essential role in vesicle trafficking and Golgi structure. GOLPH3 is localized to the trans-Golgi via tight binding to PI4P that is highly enriched at the trans-Golgi. GOLPH3 interacts and recruits the unconventional myosin MYO18A to the Golgi, allowing MYO18A and F-actin interaction. The complex applies a tensile force that pulls and deforms the Golgi membrane to facilitate vesicle budding and subsequent vesicles trafficking from the Golgi to the plasma membrane. GOLPH3/MYO18A pathway is reported to mediate DNA-PK-dependent DNA damage response that is essential for normal cell survival and, when enhanced, can confer resistance to killing by DNA damaging agents. GOLPH3 is found overexpressed in many solid tumors and cancer cell lines. Overexpression of GOLPH3 occurs frequently in rhabdomyosarcoma and GOLPH3 knockdown impairs the proliferation of rhabdomyosarcoma cell lines.
| Supplier | Creative Biogene |
|---|---|
| Product # | PAB1056 |
| Pricing | Inquiry |
| Research Area | Primary Antibodies/Antibody |
| Antibody Target | GOLPH3GPP34 |
| Antibody Type | Polyclonal |
| Application | WB, ICC |
| Formulation | Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Appearance | Liquid |
| Host | Rabbit |
| Species Reactivity | Human |
| Usage Statement | Our products are intended for research use only and are not to be used for other purposes, including but are not limited to in vitro diagnostic uses, ex vivo or in vivo therapeutic uses. |