MK-8133
MK-8133 is an orexin-2 selective receptor antagonist with favorable development properties. Antagonism of orexin receptors has shown clinical efficacy as a novel paradigm for the treatment of insomnia and related disorders.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1331 |
| CAS # | 1431472-56-8 |
| Pricing | Customizable size, Inquiry |
| Synonym | MK-8133; MK 8133; MK8133. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C23H21N5O2 |
| Exact Mass | 399.1695 |
| Molecular Weight | 399.454 |
| Elemental Analysis | C, 69.16; H, 5.30; N, 17.53; O, 8.01 |
| IUPAC/Chemical Name | 2-(((3R,6R)-6-methyl-1-(2-(pyrimidin-2-yl)benzoyl)piperidin-3-yl)oxy)isonicotinonitrile |
| InChi Key | MMRBNOXAAQLWLU-SJLPKXTDSA-N |
| InChi Code | InChI=1S/C23H21N5O2/c1-16-7-8-18(30-21-13-17(14-24)9-12-25-21)15-28(16)23(29)20-6-3-2-5-19(20)22-26-10-4-11-27-22/h2-6,9-13,16,18H,7-8,15H2,1H3/t16-,18-/m1/s1 |
| SMILES Code | O=C(N1C[C@H](OC2=NC=CC(C#N)=C2)CC[C@H]1C)C(C=CC=C3)=C3C4=NC=CC=N4 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |